b-ARG1 inhibition by compounds 15a–h.
| |||||||
|---|---|---|---|---|---|---|---|
| Cpd | R1 | R2 | R3 | R4 | R5 | IC50 ± SE (μM) | |
| 1 | 15a | — | — | F | — | — | 507 ± 10 |
| 2 | 15b | — | F | F | — | — | 312 ± 28 |
| 3 | 15c | F | F | F | F | F | 1091 ± 87 |
| 4 | 15d | — | OH | OH | — | 254 ± 42 | |
| 5 | 15e | — | OH | OH | OH | — | 287 ± 20 |
| 6 | 15f | OH | OH | OH | — | — | 532 ± 83 |
| 7 | 15g | — | — | OH | — | — | 1925 ± 111 |
| 8 | 15h | — | OH | — | — | — | 120 ± 12 |
| 9 | Sulfuretin | 437 ± 95 | |||||