Figure 4.

Latent space representation using the 11 FHs and the 0th global FH. Importantly, HADES can be used to create a latent space representation of the DMT neuroimaging data that immediately brings out important spacetime differences. (A) Here we show the figures with latent space representation using the first three FHs for visualization of the neuroimaging data. The green colour shading represents the temporal trajectory embedded in the three latent spatial dimensions of the FHs of DMT pre, PCB pre and PCB post. As can be immediately seen for the DMT-induced state (DMT post), there is a clear contraction of the contribution of the FHs across board (shown in red colour shading). (B) This can be directly quantified in terms of the latent dimension spread computed for all the 11 FHs and the 0th global FH i.e. 12th dimensional space for the four conditions. As can be seen, DMT post is significantly different from DMT pre and PCB post (green star: P < 0.05, Bonferroni corrected paired t-test).