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. 2024 May 22;19(5):e0303892. doi: 10.1371/journal.pone.0303892

Table 1. Definition of a (first) SARS-CoV-2 infection in CoMMinS versus SIS-1.

CoMMinS SIS-1
Survey data Date of:• a positive research SARS-CoV-2 infection PCR test
• SARS-CoV-2 anti-NP antibody conversion from negative to positive1
• a positive SARS-CoV-2 anti-NP antibody assay1
• a self-reported SARS-CoV-2 infection
Date of:• a positive research SARS-CoV-2 infection PCR test
• SARS-CoV-2 anti-NP antibody conversion from negative to positive1
• a positive SARS-CoV-2 anti-NP antibody assay1
• a self-reported SARS-CoV-2 infection
Linked EHR data Date of:
• BNSSG SWD primary care attributes data table: a confirmed SARS-CoV-2 infection or SARS-CoV-2 diagnosis code
• SGSS: a positive SARS-CoV-2 infection PCR test
• SUS: a confirmed SARS-CoV-2 infection or SARS-CoV-2 diagnosis code
Date of:
• GDPPR: a confirmed SARS-CoV-2 infection or SARS-CoV-2 diagnosis code
• SGSS: a positive SARS-CoV-2 infection PCR test
• HES: a confirmed SARS-CoV-2 infection or SARS-CoV-2 diagnosis code

PCR: Polymerase Chain Reaction; anti-NP: anti-nucleoprotein; BNSSG SWD: Bristol, North Somerset, and South Gloucestershire System Wide Dataset; SGSS: Second Generation Surveillance System; GDPPR: COVID-19 General Practice Extraction Service (GPES) Data for Pandemic Planning and Research. 1Only if prior to first vaccine dose, i.e., reflecting natural infection rather than vaccine-derived immunity.