Table 2. Example power calculations based on SIS-1 (using N = 14,800 CYP).
| Odds ratio | RQ1: Acute symptomatic SARS-CoV-2 infection (cases; versus asymptomatic SARS-CoV-2 infection [controls]) and risk factors (exposure)1 | RQ2: SARS-CoV-2 infection (exposure; versus no infection) and long-term outcomes2 | ||
|---|---|---|---|---|
| Percentage with risk factor in control group | Estimated power | Outcome risk in unexposed group | Estimated power | |
| 2.0 | 10% | 68.1% | 1% | 93.7% |
| 15% | 80.2% | 5% | 100% | |
| 20% | 86.7% | 10% | 100% | |
| 1.5 | 10% | 27.7% | 1% | 43.1% |
| 15% | 35.5% | 5% | 98.8% | |
| 20% | 41.5% | 10% | 100% | |
All calculations assume 95% significance level. 1Assuming an approximate control to case ratio of 2:1 and 150 symptomatic cases; 2Assuming an overall sample size of 14,800 and an estimated infection rate of 15%.