Table 1. Biospecimen collection.
| Study visit (GA) | Delivery | |||
|---|---|---|---|---|
| Study visit 1 (<16 wk) | Study visit 2 (20–29 wk) | Study visit 3 (36+ wk) | ||
| Clinical visits | ||||
| Ultrasound evaluation of uterine artery Dopplers | X | X | ||
| mp-MRI (GA: 14–16 and 19–22 wk) | X | X | ||
| Environmental exposures | ||||
| Environmental surveys | X | X | X | |
| Air quality monitors | X | X | X | |
| Biosamples | ||||
| Blood processed (10 mL) to plasma (3 mL) | X | X | X | X |
| Blood processed (20 mL) to serum (6 mL) | X | X | X | X |
| Urine (50 mL) | X | X | X | X |
| Placenta (frozen and formalin fixed) | X | |||
| Fetal membranes | X | |||
| Umbilical cord segment | X | |||
| Placenta processed with RNA later | X | |||
| Umbilical cord (2 cm) | X | |||
| Cord blood (EDTA for plasma) | X | |||
| Cord blood (blue top for plasma) | X | |||
| Cord blood red top for serum | X | |||
Abbreviations: GA, gestational age; mp-MRI, multiparametric magnetic resonance imaging.