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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Nat Cell Biol. 2023 Nov 16;25(12):1860–1872. doi: 10.1038/s41556-023-01269-8

Extended Data Fig. 5: Intracellular localization of LPS is EV-dependent.

Extended Data Fig. 5:

(a–d) Confocal microscopy of Casp11−/− iBMDMs stimulated for 4 h with unlabeled EVs (a), FITC-LPS (b), FITC-LPS-EVs (c), or CellBrite Steady Membrane 488-labeled-EVs (d) and stained with anti-CD45, anti-EEA1 and anti-FITC antibodies to visualize plasma membrane, early endosomes and LPS, respectively. Arrows indicate intracellular localization of EV-bound FITC-LPS (c) or CellBrite 488-labeled-EVs (d). Images representative of two experiments are shown. Scale bar: 5 μm.