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. 2024 May 8;629(8013):878–885. doi: 10.1038/s41586-024-07385-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a-c, Plaque assay neutralization of (a) Delta, (b) Omicron BA.1 and (c) Omicron BA.1.1 viruses. Data are represented as the normalized infection of mAb-treated virus to virus treated with control human IgG (Invitrogen). For S309, each point shows one of four technical replicates; all other points show one of two technical replicates at each concentration. Curves are two-parameter (IC50, hill-slope) logistic fits to normalized response. d, IC50 values (ng/ml, “>” indicates IC50 greater than 10,000 ng/mL) show that 2130-1-0104-024, while having only two mutations from COV2-2130, remains potent against BA.1 and suffers a 20-times loss in potency against BA.1.1. 2130-1-0114-112 is strongly potent against all three tested variants. All analysis performed in GraphPad Prism.