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. 2024 May 8;629(8013):878–885. doi: 10.1038/s41586-024-07385-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, f, COV2-2130 and 2130-1-0114-112 potently neutralize WA1/2020 D614G. b, COV2-2130 does not potently neutralize BA.1, whereas 2130-1-0114-112 does, consistent with other pseudoviral neutralization assays. c, 2130-1-0114-112 potently neutralizes BA.2.75, outperforming COV2-2130 by 90-fold. d, e, 2130-1-0114-112 loses substantial potency in the context of BA.4.6 and artificially-produced BA.2.75 + R346T but retains measurable neutralization, demonstrating mitigation of this critical weakness of COV2-2130. g-j, 2130-1-0114-112 maintains weak neutralization of BA.2.75 R346T F486S (g), but loses detectable neutralization activity against BQ.1.1 (h) and XBB (i) and exhibits a near-complete loss of neutralization activity against BN.1 (j). Symbols indicate two independent technical replicates at each concentration. Curves represent a four-parameter logistic curve fit to the data with fixed minimum and maximum values (0 and 100, respectively). k, Neutralization IC50 values in ng/ml. “>” indicates IC50 greater than 10,000 ng/mL. “NC” indicates failure to converge. All analysis conducted in GraphPad Prism.