Extended Data Fig. 7. Single base substitution signatures showing significant differences in attributed mutation burden between countries.

Signatures SBS40a (a) and SBS40b (b) were more prevalent in high-incidence regions of Czech Republic and Lithuania. Signatures SBS22a (c) and SBS22b (d) were enriched in Romania and Serbia. SBS1 (e), SBS5 (f) and SBS4 (g) showed moderate differences across countries. Signature SBS12 (h) is highly prevalent in Japan. Five SBS1 hypermutators above mutation burden of 1000 were removed for clarity. Box and whiskers plots are in the style of Tukey. The line within the box is plotted at the median while the upper and lower ends are indicated 25th and 75th percentiles. Whiskers show 1.5*IQR (interquartile range) and values outside it are shown as individual data points. N = 961 biologically independent samples examined over 1 independent experiment.