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. 2024 May 1;629(8013):910–918. doi: 10.1038/s41586-024-07368-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — PCA performed on relative mutation counts of all ccRCC tumors incorporating the six mutation classes (C > A, C > G, C > T, T > A, T > C, T > G). Principal component 1 (PC1) clearly separates the cluster of mostly Romanian cases that are enriched with AA signatures, often at high mutation burdens. Principal component 3 (PC3) identifies a cluster of mostly Japanese cases, enriched with signature SBS12.