Table 3.

Characteristics and medication lists for patients with persistent grade 3 or greater laboratory abnormalities (n = 9 patients with 10 abnormalities)

	Type of abnormality	Condition treated	Concurrent meds	Change in meds before abnormality?	Naranjo score for Hydroxychloroquine
Patient 1	Glucose	Sarcoidosis	Glimepiride, Sertraline, Losartan, Ranitidine, Metformin	No	0, doubtful
Patient 2	Lymphocyte	Livedo reticularis	Amlodipine, Aspirin	No	2, possible
Patient 3	Hemoglobin	Systemic lupus erythematous	Mycophenolate, Amlodipine, Spironolactone, Losartan, Chlorthalidone	Mycophenolate increased to 500 mg BID at appointment 1 month prior	1, possible
Patient 4 (2 abnormalities)	Alanine transferase, Alkaline phosphatase	Rheumatoid arthritis	Hydroxyzine, Sertraline, Fexofenadine, Ursodiol, Rifampin	No	0, doubtful
Patient 5	Lymphocyte	Systemic lupus erythematous	Omeprazole, Mycophenolate Prednisone, Amlodipine, Lisinopril	Prednisone started 2–3 weeks prior	1, possible
Patient 6	Glucose	Rheumatoid arthritis	Insulin lispro, Atorvastatin, Candesartan, Metformin, Tamsulosin, Methotrexate, Metoprolol	Atorvastatin increased to 40 mg 8 weeks prior	0, doubtful
Patient 7	GFR	Cryoglobulinemia	Aspirin, Gabapentin, Mycophenolate, Hydrochlorothiazide	No	0, doubtful
Patient 8	GFR	Systemic lupus erythematous	Furosemide, Warfarin, Benazepril, Levothyroxine, Gabapentin, Atorvastatin	Furosemide dose doubled 2 months prior	0, doubtful
Patient 9	GFR	Granuloma annulare	Pentoxifylline, remainder of meds unknown	Unknown	0, doubtful

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Adverse Drug Reaction Probability Scale (Naranjo) in Drug Induced Liver Injury. 2019 May 4. PMID: 31689026

GFR glomerular filtration rate