Table 1.
Patient demographics and baseline characteristics
| Characteristic | Cohort | p-value2 | |
|---|---|---|---|
| Training cohort, N = 7251 | Internal test cohort, N = 3101 | ||
| Maternal age | 0.625 | ||
| Median (IQR) | 39.0 (35.0, 41.0) | 39.0 (35.0, 41.0) | |
| Paternal age | 0.286 | ||
| Median (IQR) | 40.0 (35.0, 43.0) | 39.4 (35.0, 42.0) | |
| Infertility duration | 0.159 | ||
| Median (IQR) | 5.0 (3.0, 9.0) | 5.0 (3.0, 8.0) | |
| Infertility type | 0.542 | ||
| Primary infertility | 131 (18.1%) | 61 (19.7%) | |
| Secondary infertility | 594 (81.9%) | 249 (80.3%) | |
| Number of blastocysts cultured | 0.280 | ||
| Median (IQR) | 3.00 (2.00, 4.00) | 2.00 (2.00, 4.00) | |
| Normal fertilization | 0.243 | ||
| No | 114 (15.7%) | 40 (12.9%) | |
| Yes | 611 (84.3%) | 270 (87.1%) | |
| The blastomere number of D2 | 0.239 | ||
| Median (IQR) | 4.00 (4.00, 4.00) | 4.00 (4.00, 4.00) | |
| Embryo fragmentation of D2 | 0.376 | ||
| Median (IQR) | 0.0 (0.0, 5.0) | 0.0 (0.0, 5.0) | |
| Day 3 embryo grade | 0.636 | ||
| I | 390 (53.8%) | 166 (53.5%) | |
| II | 174 (24.0%) | 68 (21.9%) | |
| III | 161 (22.2%) | 76 (24.5%) | |
| Fusion embryos | 0.323 | ||
| No | 683 (94.2%) | 287 (92.6%) | |
| Yes | 42 (5.8%) | 23 (7.4%) | |
| The blastomere number of D3 | 0.064 | ||
| Median (IQR) | 8.00 (7.00, 8.61) | 8.00 (7.00, 8.98) | |
| Embryo fragmentation of D3 | 0.708 | ||
| Median (IQR) | 0.0 (0.0, 10.0) | 0.0 (0.0, 10.0) | |
| Day 2 embryo grade | 0.878 | ||
| I | 219 (30.2%) | 89 (28.7%) | |
| II | 123 (17.0%) | 55 (17.7%) | |
| III | 383 (52.8%) | 166 (53.5%) | |
| Ovarian stimulation protocol | 0.221 | ||
| Median (IQR) | 1.00 (1.00, 2.00) | 1.00 (1.00, 2.00) | |
| Type of fertilization | 0.753 | ||
| IVF | 540 (74.5%) | 228 (73.5%) | |
| ICSI | 185 (25.5%) | 82 (26.5%) | |
| Maternal BMI | 0.306 | ||
| Median (IQR) | 22.76 (20.81, 24.65) | 22.86 (20.86, 24.97) | |
| Basal FSH | 0.617 | ||
| Median (IQR) | 7.2 (5.8, 9.2) | 6.9 (5.8, 9.3) | |
| Basal LH | 0.930 | ||
| Median (IQR) | 2.60 (1.92, 3.49) | 2.59 (1.92, 3.59) | |
| Basal PRL | 0.119 | ||
| Median (IQR) | 15 (10, 20) | 16 (11, 21) | |
| Basal E2 | 0.137 | ||
| Median (IQR) | 33 (23, 48) | 30 (22, 45) | |
| Basal T | 0.621 | ||
| Median (IQR) | 0.25 (0.20, 0.31) | 0.25 (0.20, 0.30) | |
| Basal P | 0.977 | ||
| Median (IQR) | 0.30 (0.20, 0.40) | 0.30 (0.20, 0.40) | |
| AMH | 0.087 | ||
| Median (IQR) | 0.68 (0.46, 0.88) | 0.66 (0.43, 0.82) | |
| AFC | 0.395 | ||
| Median (IQR) | 4.91 (4.00, 6.00) | 4.96 (4.00, 6.00) | |
| Total Gndosage | 0.343 | ||
| Median (IQR) | 2,175 (1,610, 2,700) | 2,250 (1,735, 2,700) | |
| Duration of stimulation | 0.169 | ||
| Median (IQR) | 9.00 (7.91, 10.00) | 9.00 (8.00, 10.00) | |
| Initial FSH dosage | 0.518 | ||
| Median (IQR) | 225 (225, 300) | 225 (225, 300) | |
| Serum E2 level on the hCG trigger day | 0.314 | ||
| Median (IQR) | 1,125 (743, 1,568) | 1,093 (749, 1,577) | |
| Serum LH level on the hCG trigger day | 0.913 | ||
| Median (IQR) | 1.78 (1.20, 2.91) | 1.77 (1.16, 2.91) | |
| Serum P level on the hCG trigger day | 0.675 | ||
| Median (IQR) | 0.30 (0.20, 0.50) | 0.30 (0.20, 0.50) | |
| Volume of semen after treatment | 0.539 | ||
| Median (IQR) | 0.50 (0.50, 0.50) | 0.50 (0.50, 0.50) | |
| Semen density after treatment | 0.277 | ||
| Median (IQR) | 4.00 (2.50, 5.00) | 3.00 (2.00, 5.00) | |
| Semen recovery rate | 0.298 | ||
| Median (IQR) | 5 (3, 9) | 5 (3, 9) | |
1n (%)
2Wilcoxon rank-sum test; Pearson’s chi-squared test