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A model outlining how CMX interferes with the activity of DHFR, culminating in downstream effects and decreases in RNA synthesis. (a) Under normal conditions, DHFR converts dihydrofolate (DHF) to tetrahydrofolate (THF). This conversion is critical for production of purines, which are later used in RNA synthesis. (b) CMX inhibits the activity of DHFR, thereby reducing the conversion of DHF to THF resulting in decrease in the number of purines and therefore decreasing RNA synthesis.
