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. 2024 May 22;15:4366. doi: 10.1038/s41467-024-48838-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–g Increase in half-life time (t_1/2) of tracer nanoparticles after the induction of the MPS blockade. Red line indicates median efficiency derived from all data sets and equals to 2.3-fold increase. h Decrease of the MPS blockade efficiency over time after the administration of blocking particles. Each connected line shows a separate case of MPS blockade from the Supplementary Dataset 1. i, j Increase in the efficiency of tumour delivery for tracer nanoparticles after the induction of the MPS blockade. Red line indicates median efficiency derived from all data sets and equals to 1.4-fold increase. k Analysis of increase in blood circulation by AUC (left) and tumour delivery (right) in datasets, where tumour treatment was demonstrated. The boxes represent median, the 25th to 75th percentiles, and the whiskers show 1.5 interquartile range. Analysed data points are plotted left to the boxplots. Median values are reported on the graphs.