Table 1.
Initial parameters
| fMSC-treated cats |
Placebo cats |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 1 | 2 | 3 | 4 | |
| Age (years) | 7 | 13 | 13 | 15 | 14 | 13 | 7 | 15 | 11 | 12 | 10 |
| Sex | MC | FS | FS | FS | MC | FS | MC | FS | FS | FS | FS |
| Breed | DSH | DSH | DSH | DSH | DSH | DSH | DSH | DLH | DSH | DSH | DSH |
| Weight (kg) | 3.3 | 4.0 | 3.4 | 3.6 | 3.1 | 2.5 | 4.0 | 3.0 | 6.0 | 3.7 | 4.6 |
| BCS | 3/9 | 5/9 | 4/9 | 4/9 | 3/9 | 3/9 | 4/9 | 3/9 | 7/9 | 3/9 | 4/9 |
| Duration (months) | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >6 | >12 | >12 | >6 |
| Diarrhea | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes | No | Yes | No |
| Frequency | Once daily | Five times per week | Five times per week | Twice daily | Twice daily | Once daily | Three times daily | Three times daily | Once daily | Once daily | Once daily |
| Consistency | 5.0 | 4.5 | 4.5 | 4.5 | 6.5 | 4.0 | 6.0 | 5.0 | 3.0 | 6.0 | 3.0 |
| Vomiting | Yes | Yes | Yes | Yes | Yes | No | No | Yes | No | Yes | Yes |
| Frequency | Three times daily | Twice weekly | Once weekly | Twice monthly | Five times weekly | NA | NA | Twice weekly | NA | Once daily | Twice weekly |
| Weight loss (kg) | 1.5 | NR | NR | NR | 1.0 | 1.5 | NR | 0.5 | None | 1.0 | NR |
| Appetite | Decr | Decr | Decr | Norm | Norm | Norm | Norm | Norm | Norm | Incr | Norm |
| Diet | Nat Bal | Hill’s z/d | Hill’s z/d | RC HF | Nat Bal | Nat Bal | Friskies | Hill’s k/d | Sci Diet | Pur HA | Hill’s i/d |
| Medications | None | Pred,* Met † | Pred* | None | Pred, † Leuk § | Leuk § , Depo ¶ | None | None | Bude ∞ | Pred # | None |
| Supplements | None | FF | FF | FF | V B12 | None | V B12 | None | None | None | None |
5 mg q48h
2.5 mg q12h
5 mg q12h
2 mg twice weekly
20 mg every 6–8 weeks
1 mg q24h
5 mg q24h
BCS = body condition score; Bude = budesonide; Decr = decreased; Depo = Depo-Medrol injection (Pfizer); DLH = domestic longhair; DSH = domestic shorthair; fMSC = feline adipose-derived mesenchymal stem cells; FF = FortiFlora (Purina probiotic) once daily; Friskies = Friskies (Purina)/9Lives (Big Heart Pet Brands); FS = female spayed; Incr = increased; Leuk = Leukeran (GlaxoSmithKline); MC = male castrated; Met = methimazole; NA = not applicable; Nat Bal = Natural Balance (Big Heart Pet Brands); Norm = normal; NR = not recorded; Pred = prednisolone; Pur HA = Purina Hypoallergenic; RC HF = Royal Canin High Fiber; Sci Diet = Science Diet Adult Maintenance (Hill’s); V B12 = vitamin B12 injections 250 µg twice monthly