Table 2.
Macroscopic findings | Microscopic findings: brain | Microscopic findings: spinal cord | |
---|---|---|---|
Cat 1 | Hemorrhage – ventral brainstem/cervical SC | AD, HyD (BA), thrombosis, WM degeneration (caudal medulla) | AD (VSA) C3-C5, thrombosis, ventral funiculus WM degeneration |
Cat 2 | Hemorrhage – ventral brainstem/cervical SC (Figure 3) | HyD (meninges), thrombosis (BA branch), leptomeningeal fibrosis, acute, chronic hemorrhage (medulla) (Figure 5c). WM degeneration cerebellar peduncle hemorrhage | Cranial cervical SC, bilateral WM/GM necrosis |
Cat 3 | Red nodule (vascular ectasia [aneurysm]) – ventral C2 | HyD (meninges), mixed perivascular/vascular inflammation | AD (VSA), chronic perivascular hemorrhage, GM degeneration, hemorrhage, gliosis, HyD (C3) |
Cat 4 | Red nodules (vascular ectasia [aneurysm]) – ventral C3–C5, L3–L4, medulla (Figure 4) |
AD, HyD (BA branch), compression, midline shift, regional WM degeneration, necrosis, chromatolysis | AD, HyD (VSA) C3–C5, L3, L4, thrombosis, compression (Figures 5a,b), WM degeneration, occasional necrosis, chronic hemorrhage, inflammation |
Cat 5 | Red nodules (vascular ectasia [aneurysm]) – C7–T1, L3 | HyD (BA branches), mineralization, meningeal chronic inflammation and hemorrhage, focal cerebellar necrosis | AD, HyD (VSA) C7–T1, L3, thrombosis, compression, ventral funiculi WM degeneration, gliosis, chromatolysis |
SC = spinal cord; AD = aneurysmal dilation; HyD = hyaline degeneration; BA = basilar artery; WM = white matter; VSA = ventral spinal artery; GM = gray matter