Table 1.

Signalment, disease, treatments, development of acquired Fanconi syndrome (FS) and outcome in four cats treated with chlorambucil

	Case 1	Case 2	Case 3	Case 4
Age (y)/signalment	13/DSH Fs	13/DSH MC	12/DSH Fs	8/Persian MC
Intestinal disease diagnosis	Suspected low-grade alimentary lymphoma vs IBD	Low-grade alimentary lymphoma	Low-grade alimentary lymphoma	IBD
Chlorambucil dosage	2 mg orally twice weekly	2 mg orally three times weekly	2 mg orally three times weekly	2 mg orally twice weekly
Chlorambucil compounded?	Yes	No	Yes	Yes
Steroid formulation(s) and dosage(s) used during chlorambucil treatment period*	Prednisone 5 mg orally q24h, prednisolone 10 mg transdermally q24h, prednisolone 10 mg orally q24h	Prednisolone 10 mg orally q24h	Prednisolone 10 mg orally q24h, dexamethasone 1 mg orally q24h, budesonide 1 mg orally q24h	Budesonide 1 mg orally q24h, methylprednisolone acetate 20 mg intramuscularly
Other medications used during chlorambucil treatment period †	None	Mirtazapine, oxytetracycline ophthalmic	Cobalamin	Metronidazole, metoclopramide, lysine, idoxuridine, moxifloxacin, famciclovir, alendronate, mirtazapine, amoxicillin-clavulanate, robenacoxib, buprenorphine
Time to identification of glucosuria (months)	26	7	2	5
Time to diagnosis of FS (months) ‡	27	7	4	5
Chlorambucil discontinued	Yes	Yes	Yes	Yes
Time to resolution of FS (partial/complete)	Not resolved after 1 week	3 months (unknown, no follow-up urine assay)	6 weeks (complete)	2 months (partial)
Case outcome after FS diagnosis	Euthanized after 9 months (suspected to be unrelated to FS)	Died after 6 months (suspected to be unrelated to FS)	Alive after 10 months	Alive after 6 months

^*See text for duration and timeline of administration

^†See text for drug dosages, duration and timeline of administration

^‡Time of urine metabolic assay submission

DSH = domestic shorthair; Fs = female spayed; MC = male castrated; IBD = inflammatory bowel disease; y = years