Table 2.
Distribution of the MTHFR C677T polymorphism in the END and Non-END Groups Under Different Genetic Models.
| Genetic models | Distribution（n, %） |
Unadjusted |
Adjusteda |
|||||
|---|---|---|---|---|---|---|---|---|
| END （n = 129） |
Non-END （n = 305） |
OR | 95%CI | P_value | OR | 95%CI | P_value | |
| Allelic model | ||||||||
| T | 139 (53.9) | 259 (42.5) | 1.583 | 1.181–2.121 | 0.002 | – | – | – |
| C | 119 (46.1) | 351 (57.7) | ||||||
| Genotype | ||||||||
| TT | 40 (31.0) | 56 (18.4) | ||||||
| CT | 59 (45.7) | 147 (48.2) | ||||||
| CC | 30 (23.3) | 102 (33.4) | ||||||
| Dominant model | ||||||||
| CC | 30 (23.3) | 102 (33.4) | 0.603 | 0.376–0.968 | 0.035 | 0.748 | 0.440–1.272 | 0.284 |
| TT + CT | 99 (76.7) | 203 (66.6) | ||||||
| Recessive model | ||||||||
| TT | 40 (31.0) | 56 (18.4) | 1.998 | 1.246–3.205 | 0.004 | 1.710 | 1.021–2.863 | 0.042 |
| CC + CT | 89 (69.0) | 249 (81.6) | ||||||
Notes: END: early neurological deterioration; OR: odds ratio; 95%CI: 95%confidence interval; aOriginal values of unadjusted covariates.
a
Logistic multiple regression analysis results (adjusted variables: sex, age, WBC abnormality, drinking, smoking, diabetes history, HHcy, admission hyperglycemia, and NIHSS >5).