Table 3.
Mean annualized bleed rates for treated bleeds for people with hemophilia A with or without factor VIII inhibitors by age group and comorbidity.
| Overall pooled population (N = 504) | People with HA aged <50 y (n = 408) | People with HA aged ≥50 y (n = 96) |
|||||
|---|---|---|---|---|---|---|---|
| Total (n = 96) | ≥1 CV risk factor (n = 70) | ≥2 CV risk factors (n = 24) | HCV-positive only (n = 48) | HIV- + HCV-positive (n = 22) | |||
| All participants | |||||||
| Mean ABR for treated bleeds (95% CI) | 1.39 (0.08-6.23) | 1.29 (0.07-6.06) | 1.82 (0.19-6.93) | 1.91 (0.22-7.09) | 1.32 (0.07-6.11) | 1.59 (0.13-6.57) | 2.72 (0.50-8.34) |
| Participants with FVIII inhibitors | |||||||
| n (%) | 283 (56.2) | 234 (57.4) | 49 (51.0) | 33 (47.1) | 12 (50.0) | 28 (58.3) | 2 (9.1) |
| Mean ABR for treated bleeds (95% CI) | 1.41 (0.09-6.27) | 1.45 (0.10-6.34) | 1.22 (0.05-5.95) | 1.15 (0.04-5.84) | 0.55 (0.00-4.77) | 1.63 (0.14-6.63) | 2.65 (0.48-8.24) |
| Participants without FVIII inhibitors | |||||||
| n (%) | 221 (43.8) | 174 (42.6) | 47 (49.0) | 37 (52.9) | 12 (50.0) | 20 (41.7) | 20 (90.9) |
| Mean ABR for treated bleeds (95% CI) | 1.36 (0.08-6.18) | 1.07 (0.03-5.69) | 2.44 (0.39-7.91) | 2.59 (0.45-8.15) | 2.08 (0.27-7.35) | 1.54 (0.12-6.48) | 2.72 (0.5-8.35) |
Data from the one participant with HIV infection only have been omitted.
ABR, annualized bleed rate; CI, confidence interval; CV, cardiovascular; FVIII, factor VIII; HA, hemophilia A; HCV, hepatitis C virus.