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. 2024 Apr 23;96(20):7817–7839. doi: 10.1021/acs.analchem.4c01510

Figure 7.

Figure 7

Workflow for the fabrication and use of shaped particles. (a) Fabrication of shaped microparticles in microfluidic devices using photomasks and UV polymerization. Representative shape-encoded particles used for biomolecular detection. [From Pregibon, D. C., et al. Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis. Science2007, 315 (5817), 1393–1396 (ref (30)) reprinted with permission from AAAS; Kim, L. N., et al. Chem. Commun.2015, 51 (60), 12130–12133 (ref (133)) with permission from The Royal Society of Chemistry; and Destgeer, G., et al. Lab Chip2020, 20 (19), 3503–3514 (ref (22)) with permission from The Royal Society of Chemistry.] (b) Schematic representation of assay workflow using shaped microparticles including incubation and signal amplification steps. (c) Readout of assay results on individual microparticles using standard instrumentation such as microscopes, cell phones, or scanners. [Reproduced from Destgeer, G., et al. Lab Chip2020, 20 (19), 3503–3514 (ref (22)) with permission from The Royal Society of Chemistry; Derveaux, S., et al. Anal. Bioanal. Chem.2008, 391 (7), 2453–2467 (ref (135)) with permission from The Royal Society of Chemistry; and Svedberg, G., et al. Lab Chip2017, 17 (3), 549–556 (ref (134)) with permission from The Royal Society of Chemistry.]