Figure 2.

Signature-signature interactions in PCAWG

(A) Network summary of all detected signature-signature interactions in PCAWG. CL stands for clock-like.

(B) Heatmap of signature activities in pancreatic adenocarcinoma.

(C) Signature-signature interaction network for samples in (B).

(D) Summary of common interactions in PCAWG across tissues. Positive (red) and negative (blue) interactions are summarized separately, and the numbers indicate the number of tissues in which this interaction was detected. We filtered the displayed signatures to have at least four interactions. The infographic at the bottom right side demonstrates how common signatures across tissues were selected.

(E) Network of interactions found both in PCAWG and TCGA. The icons on the edges indicate the tissue where the interaction is observed. See also Figure S2.