Figure 3.

Signature-pathway interactions in PCAWG

(A) Summary of pathway alterations in PCAWG across tissues.

(B) Summary of signature-pathway interactions across tissues in PCAWG. Positive (red) and negative (blue) interactions are summarized separately, and the numbers indicate the number of tissues in which this interaction has been detected.

(C) Bipartite graph of signature-pathway interactions in PCAWG.

(D) Heatmap of logged signature activities in stomach adenocarcinoma (Stomach_Adeno) in PCAWG with annotated pathway alterations and two classes C1 and C2 with high and low levels of mismatch repair deficiency (dMMR) signature.

(E) Signature-pathway cooccurrence and exclusivity in Stomach_AdenoCA.

(F) Common signature-pathway interactions in TCGA and PCAWG. Icons on the edges indicate the tissue in which the interaction was detected in both datasets.