Comparison 2. Mini Mental State Examination (MMSE) change from baseline.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 MMSE change from baseline	4	1127	Mean Difference (IV, Fixed, 95% CI)	‐0.32 [‐0.71, 0.06]
2 MMSE change from baseline using random‐effects model	4	1127	Mean Difference (IV, Random, 95% CI)	‐0.88 [‐2.04, 0.28]
3 MMSE change at 3 months	2	1017	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.31, 0.38]
4 MMSE change at 6 months	4	1084	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.66, 0.05]
5 MMSE change at 12 months	4	1027	Mean Difference (IV, Fixed, 95% CI)	‐0.46 [‐0.90, ‐0.03]
6 MMSE change at 18 months	2	845	Mean Difference (IV, Fixed, 95% CI)	‐0.14 [‐0.68, 0.41]