Comparison 3. Clinical Global Impression of Change (CGIC).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 CGIC change	2	660	Mean Difference (Fixed, 95% CI)	‐0.02 [‐0.14, 0.10]
2 CGIC change at 3 months	1	603	Mean Difference (Fixed, 95% CI)	0.01 [‐0.10, 0.12]
3 CGIC change at 6 months	1	564	Mean Difference (Fixed, 95% CI)	0.03 [‐0.11, 0.18]
4 CGIC change at 9 months	1	527	Mean Difference (Fixed, 95% CI)	‐0.02 [‐0.18, 0.14]
5 CGIC change at 12 months	1	505	Mean Difference (Fixed, 95% CI)	‐0.03 [‐0.20, 0.13]
6 CGIC change at 15 months	1	486	Mean Difference (Fixed, 95% CI)	0.02 [‐0.16, 0.20]
7 CGIC change at 18 months	1	435	Mean Difference (Fixed, 95% CI)	0.12 [‐0.07, 0.31]
8 CGIC (last observation carried forward)	1	614	Mean Difference (Fixed, 95% CI)	0.16 [‐0.01, 0.33]