Source	Search strategy	Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois) [date of most recent search: 20 January 2014]	Keyword search: statin OR statins OR "Hydroxymethylglutaryl‐CoA Reductase Inhibitors"	Feb 2013: 45 Jan 2014: 0
2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950‐present (Ovid SP) [date of most recent search: 20 January 2014]	1. exp Dementia/ 2. Delirium/ 3. Wernicke Encephalopathy/ 4. Delirium, Dementia, Amnestic, Cognitive Disorders/ 5. dement*.mp. 6. alzheimer*.mp. 7. (Lewy* adj2 body*).mp. 8. deliri*.mp. 9. (chronic adj2 cerebrovascular).mp. 10. ("organic brain disease" or "organic brain syndrome").mp. 11. ("normal pressure hydrocephalus" and "shunt*").mp. 12. "benign senescent forgetfulness".mp. 13. (cerebr* adj2 deteriorat*).mp. 14. (cerebral* adj2 insufficient*).mp. 15. (pick* adj2 disease).mp. 16. (Creutzfeldt or jcd or cjd).mp. 17. Huntington*.mp. 18. Binswanger*.mp. 19. Korsakoff*.mp. 20. or/1‐19 21. (statin or statins).ti,ab. 22. atorvastatin.ti,ab. 23. cerivastatin.ti,ab. 24. fluvastatin.ti,ab. 25. lovastatin.ti,ab. 26. pravastatin.ti,ab. 27. simvastatin.ti,ab. 28. lipitor.ti,ab. 29. baycol.ti,ab. 30. lescol.ti,ab. 31. mevacor.ti,ab. 32. altocor.ti,ab. 33. pravachol.ti,ab. 34. lipostat.ti,ab. 35. zocor.ti,ab. 36. mevinolin.ti,ab. 37. compactin.ti,ab. 38. fluindostatin.ti,ab. 39. rosuvastatin.ti,ab. 40. Hydroxymethylglutaryl‐CoA Reductase Inhibitors/ or Lovastatin/ 41. Simvastatin/ 42. or/21‐41 43. 20 and 42 44. randomised controlled trial.pt. 45. controlled clinical trial.pt. 46. controlled clinical trial.pt. 47. randomized.ab. 48. placebo.ab. 49. drug therapy.fs. 50. randomly.ab. 51. trial.ab. 52. groups.ab. 53. or/44‐52 54. (animals not (humans and animals)).sh. 55. 53 not 54 56. 43 and 55 57. (2008* or 2009* or 2010* or 2011* or 2012*).ed. 58. 56 and 57	Feb 2013: 155 Jan 2014: 25
3. EMBASE 1980‐2011 week 35 (Ovid SP) [date of most recent search: 20 January 2014]	1. exp dementia/ 2. Lewy body/ 3. delirium/ 4. Wernicke encephalopathy/ 5. cognitive defect/ 6. dement*.mp. 7. alzheimer*.mp. 8. (Lewy* adj2 body*).mp. 9. deliri*.mp. 10. (chronic adj2 cerebrovascular).mp. 11. ("organic brain disease" or "organic brain syndrome").mp. 12. "supranuclear palsy".mp. 13. ("normal pressure hydrocephalus" and "shunt*").mp. 14. "benign senescent forgetfulness".mp. 15. (cerebr* adj2 deteriorat*).mp. 16. (cerebral* adj2 insufficient*).mp. 17. (pick* adj2 disease).mp. 18. (Creutzfeldt or jcd or cjd).mp. 19. Huntington*.mp. 20. Binswanger*.mp. 21. Korsakoff*.mp. 22. CADASIL.mp. 23. or/1‐22 24. exp dementia/ 25. Lewy body/ 26. delirium/ 27. Wernicke encephalopathy/ 28. cognitive defect/ 29. dement*.mp. 30. alzheimer*.mp. 31. (Lewy* adj2 body*).mp. 32. deliri*.mp. 33. (chronic adj2 cerebrovascular).mp. 34. ("organic brain disease" or "organic brain syndrome").mp. 35. "supranuclear palsy".mp. 36. ("normal pressure hydrocephalus" and "shunt*").mp. 37. "benign senescent forgetfulness".mp. 38. (cerebr* adj2 deteriorat*).mp. 39. (cerebral* adj2 insufficient*).mp. 40. (pick* adj2 disease).mp. 41. (Creutzfeldt or jcd or cjd).mp. 42. Huntington*.mp. 43. Binswanger*.mp. 44. Korsakoff*.mp. 45. CADASIL.mp. 46. or/24‐45 47. (statin or statins).ti,ab. 48. atorvastatin.ti,ab. 49. cerivastatin.ti,ab. 50. fluvastatin.ti,ab. 51. lovastatin.ti,ab. 52. pravastatin.ti,ab. 53. simvastatin.ti,ab. 54. lipitor.ti,ab. 55. baycol.ti,ab. 56. lescol.ti,ab. 57. mevacor.ti,ab. 58. altocor.ti,ab. 59. altocor.ti,ab. 60. pravachol.ti,ab. 61. lipostat.ti,ab. 62. zocor.ti,ab. 63. mevinolin.ti,ab. 64. compactin.ti,ab. 65. fluindostatin.ti,ab. 66. rosuvastatin.ti,ab. 67. hydroxymethylglutaryl coenzyme A reductase inhibitor/ 68. simvastatin/ 69. mevinolin/ 70. fluindostatin/ 71. rosuvastatin/ 72. pravastatin/ 73. atorvastatin/ or cerivastatin/ 74. or/47‐73 75. 46 and 74 76. randomised controlled trial/ 77. controlled clinical trial/ 78. (RCT or CCT).ti,ab. 79. randomly.ab. 80. placebo.ab. 81. trial.ab. 82. randomized.ab. 83. or/76‐82 84. 75 and 83 85. (2008* or 2009* or 2010* or 2011* or 2012* or 2013*).em. 86. 84 and 85	Feb 2013: 222 Jan 2014: 56
4. PsycINFO 1806‐February week 1 2013 (Ovid SP) [date of most recent search: 20 January 2014]	1. exp Dementia/ 2. exp Delirium/ 3. exp Huntingtons Disease/ 4. exp Kluver Bucy Syndrome/ 5. exp Wernickes Syndrome/ 6. exp Cognitive Impairment/ 7. dement*.mp. 8. alzheimer*.mp. 9. (Lewy* adj2 body*).mp. 10. deliri*.mp. 11. (chronic adj2 cerebrovascular).mp. 12. ("organic brain disease" or "organic brain syndrome").mp. 13. "supranuclear palsy".mp. 14. ("normal pressure hydrocephalus" and "shunt*").mp. 15. "benign senescent forgetfulness".mp. 16. (cerebr* adj2 deteriorat*).mp. 17. (cerebral* adj2 insufficient*).mp. 18. (pick* adj2 disease).mp. 19. (Creutzfeldt or jcd or cjd).mp. 20. Huntington*.mp. 21. Binswanger*.mp. 22. Korsakoff*.mp. 23. ("parkinson* disease dementia" or PDD or "parkinson* dementia").mp. 24. or/1‐23 25. (statin or statins).ti,ab. 26. atorvastatin.ti,ab. 27. cerivastatin.ti,ab. 28. fluvastatin.ti,ab. 29. lovastatin.ti,ab. 30. pravastatin.ti,ab. 31. simvastatin.ti,ab. 32. lipitor.ti,ab. 33. baycol.ti,ab. 34. lescol.ti,ab. 35. mevacor.ti,ab. 36. altocor.ti,ab. 37. pravachol.ti,ab. 38. lipostat.ti,ab. 39. zocor.ti,ab. 40. mevinolin.ti,ab. 41. compactin.ti,ab. 42. fluindostatin.ti,ab. 43. rosuvastatin.ti,ab. 44. exp Statins/ 45. randomi?ed.ab. 46. placebo.ab. 47. randomly.ab. 48. trial.ab. 49. groups.ab. 50. exp Clinical Trials/ 51. (RCT or CCT).ti,ab. 52. "double‐blind*".ti,ab. 53. or/45‐52 54. or/25‐44 55. 24 and 53 and 54 56. (2008* or 2009* or 2010* or 2011* or 2012* or 2013*).up. 57. 55 and 56	Feb 2013: 46 Jan 2014: 8
5. CINAHL (EBSCOhost) [date of most recent search: 20 January 2014]	S1 (MH "Dementia+") S2 (MH "Delirium") or (MH "Delirium, Dementia, Amnestic, Cognitive Disorders") S3 (MH "Wernicke's Encephalopathy") S4 TX dement* S5 TX alzheimer* S6 TX Lewy* N2 body* S7 TX deliri* S8 TX chronic N2 cerebrovascular S9 TX "organic brain disease" or "organic brain syndrome"  S10 TX "normal pressure hydrocephalus" and "shunt*"  S11 TX "benign senescent forgetfulness" S12 TX cerebr* N2 deteriorat*  S13 TX cerebral* N2 insufficient*  S14 TX pick* N2 disease  S15 TX Creutzfeldt or jcd or cjd S16 TX Huntington*  S17 TX Binswanger*  S18 TX Korsakoff*  S19 S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16 or S17 or S18  S20 TX statin OR statins  S21 TX atorvastatin  S22 TX cerivastatin S23 TX fluvastatin S24 TX lovastatin  S25 TX pravastatin S26 TX simvastatin S27 TX lipitor  S28 TX baycol S29 TX lescol S30 TX mevacor S31 TX altocor S32 TX pravachol S33 TX lipostat  S34 TX Zocor S35 TX mevinolin  S36 TX compactin  S37 TX fluindostatin S38 TX rosuvastatin S39 (MH "Statins") OR (MH "Rosuvastatin")  S40 (MH "Simvastatin")  S41 (MH "Atorvastatin")  S42 (MH "Fluvastatin") S43 (MH "Pravastatin")  S44 S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 S45 S19 AND S44 S46 EM 2008 S47 EM 2009 S48 EM 2010 S49 EM 2011 S50 EM 2012 S51 EM 2013 S52 S46 OR S47 OR S48 OR S49 OR S50 OR S51 S53 S45 AND S52	Feb 2013: 135 Jan 2014: 17
6. ISI Web of Knowledge [includes: Web of Science (1945‐present); BIOSIS Previews (1926‐present); MEDLINE (1950‐present); Journal Citation Reports] ‐ BIOSIS Previews NOT searched [date of most recent search: 20 January 2014]	Topic=(dement* OR alzheimer* OR "Lewy body*" OR DLB OR "vascular cognitive impairment*" OR FTD OF FTLD OR "cerebrovascular insufficienc*") AND Topic=(statin OR statins OR atorvastatin or cerivastatin or fluvastatin or lovastatin or pravastatin or simvastatin or lipitor or baycol or lescol or mevacor or altocor or pravachol or lipostat or zocor or mevinolin or compactin or fluindostatin or rosuvastatin OR "Hydroxymethylglutaryl‐CoA Reductase Inhibitor*") AND Topic=(random* OR placebo OR "double‐blind*" OR trial OR RCT OR CCT) AND Year Published=(2008‐2013) Timespan=All Years. Search language=English	Feb 2013: 179 Jan 2014: 19
7. LILACS (BIREME) [date of most recent search: 20 January 2014]	dementia OR demência OR alzheimer [Words] and statin OR statins OR Hydroxymethylglutaryl‐CoA Reductase Inhibitors [Words]	Feb 2013: 8 Jan 2014: 2
8. CENTRAL (The Cochrane Library) (Issue 2 of 4, 2011) [date of most recent search: 20 January 2014]	#1 MeSH descriptor: [Dementia] explode all trees #2 MeSH descriptor: [Delirium] this term only #3 MeSH descriptor: [Wernicke Encephalopathy] this term only #4 MeSH descriptor: [Delirium, Dementia, Amnestic, Cognitive Disorders] this term only #5 dement* #6 alzheimer* #7 "Lewy* body*" #8 deliri* #9 "chronic cerebrovascular" #10 "organic brain disease" or "organic brain syndrome" #11 "normal pressure hydrocephalus" and "shunt*" #12 "benign senescent forgetfulness" #13 "cerebr* deteriorat*" #14 "cerebral* insufficient*" #15 "pick* disease" #16 Creutzfeldt or jcd or cjd #17 Huntington* #18 Binswanger* #19 Korsakoff* #20 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 #21 statin or statins #22 atorvastatin or cerivastatin or fluvastatin or lovastatin or pravastatin or simvastatin or lipitor or baycol or lescol or mevacor or altocor or pravachol or lipostat or zocor or mevinolin or compactin or fluindostatin or rosuvastatin #23 #21 or #22 #24 MeSH descriptor: [Hydroxymethylglutaryl‐CoA Reductase Inhibitors] explode all trees #25 #23 or #24 #26 #25 and #20 #27 #26 from 2008 to 2013	Feb 2013: 98 Jan 2014:
9. Clinicaltrials.gov (www.clinicaltrials.gov) [date of most recent search: 20 January 2014]	Interventional Studies | dementia OR alzheimer OR alzheimers OR Lewy OR vascular cognitive impairment | statin OR statins OR Hydroxymethylglutaryl‐CoA Reductase Inhibitors | received from 01/01/2008 to 02/13/2013	Feb 2013: 10 Jan 2014: 1
10. ICTRP Search Portal (apps.who.int/trialsearch) [includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry ‐ India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register] [date of most recent search: 20 January 2014]	Interventional Studies | dementia OR alzheimer OR alzheimers OR Lewy OR vascular cognitive impairment | statin OR statins OR Hydroxymethylglutaryl‐CoA Reductase Inhibitors | received from 01/01/2008 to 02/13/2013 [Status: ALL]	Feb 2013: 80 Jan 2014: 0
TOTAL before de‐duplication		Feb 2013: 915 Jan 2014: 132
TOTAL after de‐dupe and first‐assess		Feb 2013: 110 Jan 2014: 27