Table 3.
Allele frequencies of two IL-6 polymorphisms among COVID-19 patients with severe and mild symptoms
| Mild cases (N = 138) | Severe cases (N = 132) | OR [95% CI]a | P-Value | |
|---|---|---|---|---|
|
rs1800795 Codominant |
||||
| G/G | 101 (73.2) | 103 (78.0) | Reference | |
| G/C | 35 (25.4) | 23 (17.4) | 0.42 [0.18–0.98] | 0.09 |
| C/C | 2 (1.4) | 6 (4.6) | 2.14 [0.20–22.93] | |
| Recessive model, n (%) | ||||
| G/G + G/C | 136 (98.5) | 126 (95.5) | Reference | – |
| C/C | 2 (1.5) | 6 (4.5) | 2.56 [0.24–26.87] | 0.41 |
| Dominant model, n (%) | ||||
| G/G | 101 (73.2) | 103 (78.0) | Reference | – |
| G/C + C/C | 37 (26.8) | 29 (22.0) | 0.51 [0.23–1.13] | 0.10 |
| Overdominant model, n (%) | ||||
| G/G + C/C | 103 (74.6) | 109 (82.6) | Reference | |
| G/C | 35 (25.4) | 23 (17.4) | 0.41 [0.18–0.96] | 0.03 |
| Alleles frequencies ± SD | ||||
| G | 0.86 ± 0.02 | 0.87 ± 0.02 | Reference | – |
| C | 0.14 ± 0.02 | 0.13 ± 0.02 | 0.93 [0.57–1.52] | 0.77 |
|
rs1800797 Codominant |
||||
| G/G | 101 (73.2) | 102 (77.3) | Reference | – |
| A/G | 35 (25.4) | 24 (18.2) | 0.44 [0.19–1.04] | 0.12 |
| A/A | 2 (1.4) | 6 (4.5) | 2.17 [0.20–23.21] | |
| Recessive model, n (%) | ||||
| A/G + G/G | 136 (98.5) | 126 (95.5) | Reference | – |
| A/A | 2 (1.5) | 6 (4.5) | 2.56 [0.24–26.87] | 0.41 |
| Dominant model, n (%) | ||||
| GG | 101 (73.2) | 102 (77.3) | Reference | – |
| A/A + A/G | 37 (26.8) | 30 (22.7) | 0.53 [0.24–1.19] | 0.12 |
| Overdominant model, n (%) | ||||
| G/G + A/A | 103 (74.6) | 108 (81.8) | Reference | |
| A/G | 35 (25.4) | 24 (18.2) | 0.43 [0.19–1.01] | 0.05 |
| Alleles frequencies ± SD | ||||
| G | 0.86 ± 0.02 | 0.86 ± 0.02 | Reference | – |
| A | 0.14 ± 0.02 | 0.14 ± 0.02 | 0.96 [0.59–1.56] | 0.87 |
a OR and 95% CI were evaluated using logistic regression, adjusted for Age and sex