Fig. 2.

Molecular representation of a Cx50 hemichannel. Each protomer of the hexameric hemichannel is shown in ribbon representation in a different color. The position of the plasma membrane delimiting the extracellular and intracellular regions is represented in gray. The inset to the right highlights the location of the intracellular pocket in one of the protomers. Key residues are represented in sticks. The volume of the intracellular pocket that would be occupied by water molecules is shown in aqua