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. 2024 May 23;16:115. doi: 10.1186/s13195-024-01469-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Ranking of different biomarker combination models sorted by the AUC. AUC (95% CI) ranking in the total participants from the J-TRC cohort (n = 474) (A), in the CDR 0 participants from the J-TRC cohort (n = 331) (B), in the CDR 0.5 participants from the J-TRC cohort (n = 143) (C), in the total participants from the BioFINDER cohort (n = 177) (D), in the CU participants from the BioFINDER cohort (n = 114) (E), in the MCI participants form the BioFINDER cohort (n = 63) (F). Dotted lines represent the results for biomarkers, while solid lines represent the results for biomarkers with clinical information. AUC values are shown in the right side of each line. CI: clinical information including age, sex, and APOE, CDR: clinical dementia rating (global score), CU: cognitively unimpaired, MCI: mild cognitive impairment