Fig. 3.

Impairment of synaptic plasticity in the hippocampal CA1 region of POCD mice. A Golgi staining images of 4 × in the hippocampus under electron microscope. Scale bar, 500 μm. B Profile images of Golgi staining of neurons in the hippocampal CA1 region. 20 × with camera tracings and 60 × for spine counting. Scale bar, 100 μm for 20 ×; 10 μm for 60 ×. C Quantification of dendritic intersections *p < 0.05, **p < 0.01 (n = 18). D Quantitation of the dendritic spine density **p < 0.01 (n = 18). E Quantitation of the total dendritic length **p < 0.01 (n = 18). F The sample image shows stimulation given at the location of the lateral Schaffer branch and recorded in the CA1 region. G LTP recorded in the CA1 region of the hippocampus. The arrow indicates the point in time of the TBS. H Average field excitatory postsynaptic potential (fEPSP) slope during the last 20 min after TBS. **p < 0.01 (n = 5)