Table 2.
Roles of miRNAs in the pathogenesis and treatment of IBD.
| miRNAs | Expression | Mechanism | Results | References |
|---|---|---|---|---|
| miR-375-3p | Downregulated | Promote the transcription of solute carrier family 11 member 2 | Promote the colonic epithelial cells ferroptosis and UC progression | Chen et al. 136 |
| miRNA-9a-5p | Downregulated | miRNA-9a-5p agomir inhibits ROS production by targeting NOX4 | Prevent intestinal inflammatory damage | Li et al. 137 |
| miR-141-3p | Downregulated | miR-141-3p targets SUGT1 and inhibits its expression to inhibit colonic epithelial cells pyroptosis | Alleviate ulcerative colitis | Yan et al. 138 |
| let-7b | Downregulated | let-7b targets TGFBR1 and inhibits its expression and inhibits the profibrotic polarization of macrophages | Ameliorate intestinal fibrosis | Xu et al. 35 |
| miR-222-3p | Upregulated | miR-222-3p suppression can promote the downstream expression of Brahma-related gene 1, activate Nrf2/HO-1 signaling and reduce oxidative stress | Downregulated miR- miR-222-3p play a protective role IBD | Wang et al. 139 |
| miR-155 | Upregulated | Nogo-B deficiency inhibits miR-155 maturation in macrophages | MiR-155 inhibition reduces DSS-induced colitis in mice | Zheng et al. 140 |
| miR-142-5p | Upregulated | miR-142-5p was downregulated by overexpressed circRNA CCND1, which increases its downstream nuclear receptor coactivator-3 expression | Downregulated miR-142-5p play a protective role in IBD | Xiang et al. 141 |
| miR-7 | / | miR-7 silencing could activate epidermal growth factor receptor pathway | Alleviate the pathology of DSS-induced colitis | Zhao et al. 142 |
| miR-464 | / | miR-464 upregulated by Obefazimod | Decrease pro-inflammatory factors such as IL-6 and IL-17 | Apolit et al. 143 |
| miR-124-3p | / | miR-124-3p targets RBP4 and reduces the binding of RBP4 to NLRP3 and inhibit NLRP3-mediated pyroptosis | Alleviate UC | Yuan et al. 144 |
“/” indicates that the reference is not mentioned or is unclear. DSS: dextran sulfate sodium; IBD: inflammatory bowel disease; IL: interleukin; miRNA: micro RNA; NOX4: nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4; RBP4: retinol-binding protein 4; ROS: reactive oxygen species; SUGT1: SGT1 Homolog, MIS12 Kinetochore Complex Assembly cochaperone; TGFBR1: transforming growth factor beta receptor 1; UC: ulcerative colitis.