Fig. 2.

A schematic diagram showing the presynaptic defects in ADF/cofilin mutant mice. Compared to controls (a), the distribution of synaptic vesicles within the presynaptic bouton is changed in double mutants lacking cofilin1 and ADF (b) [24]. Moreover, the number of docked vesicles is increased. Electrophysiological experiments revealed an impairment in the recruitment of synaptic vesicles (indicated by a thinner arrow in the presynaptic terminal of double mutants when compared to controls) and an increase in synaptic vesicle exocytosis [24, 25]. No such defects were noted in cofilin1 or ADF single mutants [18, 21], thereby demonstrating that cofilin1 and ADF have redundant and overlapping functions in presynaptic physiology