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Structure of a colon crypt and its neurovascular microenvironment. Crypt stem cells and colonocytes are in close connection with microvessels, enteric neurons, and glial cells. Inset 1 shows a hypothetical condition where not only a crypt stem cell is damaged genetically, but rather all cells within crypt microenvironment, namely enteric neurons, glial cells, and microvessels (endothelial cells), undergo DNA damage
