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Components and formulation of RONDEL. The formulation consists of two vials, one with the siRNA and the other with the delivery components (CDP, AD-PEG, and AD-PEG-Tf). When the content from the two vials is mixed, the components self-assemble into RONDEL nanoparticles of approximately 70 nm, where the siRNA is fully encapsulated within the CDP polymer
