Table 2.

SWOT analysis of the pharmacogenetic studies applied to antidepressant therapy

Strengths	Weaknesses
To help the proportion of patients not responding sufficiently or suffering adverse effects during treatment  To use genetic markers for prediction of treatment outcome	Inadeguate sample size  Lack of replication  Differences in diagnosis (linked to different versions of the HAM-D used)  Use of different classes of antidepressants and/or different agents of same class  Differences in dosages
Opportunities	Threats
Discovery of clinically useful predictors  Shedding light on mechanisms of drug action  Identification of new targets not directly involved in mechanism of action	Phenotype definition  Diagnostic uncertainty