Fig. 4.
A general reaction mechanism describing any ligand-gated ion channel that accommodates the binding of two ligand molecules. Un-, mono- and di-liganded shut (S), open (O), and desensitized (D) configurations are shown. The forward and backward arrows between connected states are associated with corresponding rate constants, which quantify the transition frequencies to and from the states. Only the diliganded opening (β), shutting (α), entry into desensitized (δ), and ligand dissociation (k−1) rate constants are shown