TABLE 2.
RNA‐Seq list of differentially expressed genes that resulted downregulated in hDFs from both young and old donors.
| HGNC_symbol | logFC_Y | p value_Y | Adj. p value_Y | logFC_O | p value_O | Adj. p value_O |
|---|---|---|---|---|---|---|
| SFXN1 | 1.0844 | 0.0000 | 0.0033 | 1.1452 | 0.0004 | 0.3101 |
| ISY1‐RAB43 | 7.9681 | 0.0000 | 0.0035 | 6.8368 | 0.0412 | 0.7262 |
| NYNRIN | 1.1464 | 0.0000 | 0.0035 | 1.0762 | 0.0005 | 0.3101 |
| PPARGC1A | 1.5904 | 0.0001 | 0.0068 | 1.1916 | 0.0022 | 0.4400 |
| KCNS2 | 2.0922 | 0.0001 | 0.0069 | 1.6809 | 0.0009 | 0.3334 |
| FGD4 | 1.5381 | 0.0002 | 0.0102 | 1.3743 | 0.0018 | 0.4207 |
| PODN | 1.7383 | 0.0003 | 0.0102 | 1.6329 | 0.0007 | 0.3101 |
| KIT | 2.3093 | 0.0003 | 0.0115 | 2.1415 | 0.0004 | 0.3101 |
| TMEM35A | 1.0086 | 0.0004 | 0.0118 | 1.2386 | 0.0437 | 0.7361 |
| MAPT | 1.8248 | 0.0004 | 0.0119 | 1.5075 | 0.0479 | 0.7638 |
| CD34 | 1.3339 | 0.0006 | 0.0151 | 2.0415 | 0.0200 | 0.6171 |
| DCN | 1.0076 | 0.0008 | 0.0175 | 1.1757 | 0.0035 | 0.4773 |
| ELFN1 | 1.9332 | 0.0010 | 0.0197 | 1.3212 | 0.0165 | 0.6110 |
| TSPAN11 | 1.4086 | 0.0013 | 0.0220 | 2.5820 | 0.0074 | 0.5296 |
| PTGIS | 1.0963 | 0.0015 | 0.0232 | 1.0470 | 0.0001 | 0.2030 |
| TAFA5 | 1.6712 | 0.0016 | 0.0245 | 1.5207 | 0.0420 | 0.7315 |
| BRINP1 | 2.1674 | 0.0018 | 0.0261 | 1.6062 | 0.0026 | 0.4530 |
| FAM43A | 1.0912 | 0.0020 | 0.0273 | 1.0810 | 0.0131 | 0.5934 |
| HMGA2‐AS1 | 1.3809 | 0.0050 | 0.0449 | 1.2484 | 0.0165 | 0.6110 |
Note: Only the genes with BH‐adjusted p value <0.05 in hDFs from young donors are listed in this table.
Abbreviations: Adj. p value, BH‐adjusted p value; HGNC, gene name according to HUGO Gene Nomenclature Committee; logFC, log2‐transformed fold change; O, in old group; Y, in young group.