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Potential reaction mechanism of the NirDLGH-catalyzed double decarboxylation. The double decarboxylation of siroheme is catalyzed by the NirDLGH and occurs via the formation of an iminium ion. Here, ring D is shown to undergo decarboxylation at position C18 prior to the decarboxylation of the acetate side chain at ring C. The actual order of these transformations is not known
