Fig. 1.

Components of the NF-κB signaling pathway. Alternative nomenclatures appear in brackets. The respective domains of each protein family are indicated with RHD REL homology domain, TAD transactivation domain, LZ leucine zipper, GRR glycine-rich region, ANK ankyrin repeat, DD death domain, KD kinase domain, NLS nuclear localization sequence, SDD α-helical scaffold/dimerization domain, HLH helix–loop–helix, CC coiled coil, HLX helix, NUB NEMO ubiquitin binding, Pro(n) proline rich region, ZF zinc finger. Residues modified by phosphorylation or ubiquitination are also shown