Fig. 1.
The myriad of factors regulating regucalcin (RGN) gene expression. Some exert up-regulation effects (solid arrows) while others up-regulated or down-regulated RGN expression (dashed arrows) depending on the cell type, doses and/or time of stimulation. Bar-headed arrow represents inhibition. T3 Triiodothyronine, DHT 5α-dihydrotestosterone, E 2 17β-estradiol, PTH parathyroid hormone, LPS lipopolysaccharide, CCl 4 carbon tetrachloride, CaM calmodulin, PKC protein kinase C, ER estrogen receptor, PTHR parathyroid hormone receptor, CTR calcitonin receptor, InsR insulin receptor, TrK tyrosine kinase, TR thyroid hormones receptor, AR androgen receptor, MR mineralocorticoid receptor, OS oxidative stress