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Schematic representation of regucalcin (RGN) actions on enzymes involved in intracellular signaling and metabolism. Arrows indicate activation by RGN and bar-headed arrows represent inhibition. RGN decreases NOS, PK and succinate dehydrogenase enzymes activity. RGN also inhibits Ca2+/CaM dependent activation of PKC, cAMP phosphodiesterase and phosphatases.NOS nitric oxide synthase, PK pyruvate kinase, CaM calmodulin, PKC protein kinase C
