Fig. 1.

Structure of SLAP. The SLAP gene is expressed as 5 transcript variants. Variants a, b and c contain intact SH2 and SH3 domains, while the d variant lacks functional SH2 domain and the e variant lacks both domains. The functional domains of SLAP are highly conserved between species including human, mouse, chicken and frog. The uncharacterized C-terminal region displays comparatively poor conservation. SLAP shares considerable sequence similarity with its homolog SLAP2. SLAP has a similar domain structure as SRC except for the presence of a functional kinase domain in SRC