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SLAP in regulation of BCR signaling. Activation of BCR results in the activation of AKT, NF-κB and NFAT signaling through different mechanisms. SLAP binds to the BCR components Igα and SYK through its SH2 domain and then recruits CBL resulting in negative regulation of all three pathways. SLAP destabilizes SYK and BCR Igα which are intermediate signaling components of BCR signaling
