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SLAP in regulation of EPOR signaling. Activation of the EPOR results in the activation of AKT, STAT5 and ERK1/2 signaling. SLAP counteracts EPOR signaling probably by recruiting CBL to the EPOR. CBL-dependent degradation of EPOR results in weaker activation of AKT, STAT5 and ERK1/2. Therefore, SLAP negatively regulates all three pathways
