Fig. 5.

SLAP in regulation of RTK signaling. Activation of RTK signaling results in the activation of AKT, p38, STAT5 and ERK1/2 signaling through different mechanisms. SLAP binds to RTKs and display different functions. SLAP associates with phospho-tyrosine residues of the activated receptor through its SH2 domain. While SLAP association increases receptor ubiquitination and accelerates the degradation, it both negatively and positively regulates receptor signaling depending on the receptor type