Table 1.

Features of whole genome sequencing (WGS) vs. whole exome sequencing (WES)

Feature	WGS	WES
Exonic variants	Yes	Yes
Intronic variants	Yes	No
Intergenic variants	Yes	No
Indels	Yes	Yes
Copy number variations	Yes	Not directly/imprecise
Large insertions and deletions	Yes	Not directly/imprecise
Transposable elements	Yes	Not directly/imprecise

Detection of copy number variations, large insertion and deletions, as well as of transposable elements are imprecise in WES since data are available for coding regions only, and these events can originate elsewhere