Fig. 2.

Proper AM dosage is required for normal lymphangiogenesis during development and in tumor biology. a Precise AM concentration is required during development to regulate LEC proliferation. Absent AM signaling results in small, hypoplastic lymphatic sacs. Conversely, loss of the decoy receptor, CXCR7, results in excessive AM signaling and enlarged, hyperplasic lymphatic sacs. b Similarly, overexpression of Adm in tumor models results in enhanced proliferation of LECs, dilated lymphatics, and increased tumor metastasis