Fig. 2.

Characteristics of reticular fiber and fibrotic networks. The reticular fiber network of secondary and tertiary lymphoid organ is composed of light and spaced fibers made by FRC. This network provides a guidance path for T cells that migrate rapidly onto FRC coated with chemokines (left). Fibrotic networks are characterized by dense and parallel matrix fibers generated by activated fibroblasts. Fibrotic networks are unfavorable migration zone for T cells which hardly move between dense fibers (right). Features of both networks are described in Table 1