Table 1.

Effects of GNPs on MCF7 cells

Parameter	Condition	Result
Mitochondrial metabolic activity	Small gold nanospheres	↓↓↓
	Gold nanoflowers	↓↓
	Big gold nanospheres	↔
De novo RNA synthesis in nucleoli	Small gold nanospheres	↓↓↓
	Gold nanoflowers	↓↓
	Big gold nanospheres	↔/↓
De novo RNA synthesis in nucleoli	Small gold nanospheres + heat shock	↓↓↓↓
	Gold nanoflowers + heat shock	↓↓↓↓
	Big gold nanospheres + heat shock	↓↓↓↓

The impact of different GNPs on MCF7 cell viability and nucleolar activity is summarized. ↓ decrease in activity, ↔ little effect. Note that the outcomes are similar for cell survival (as indicated by mitochondrial metabolic activity) and de novo RNA synthesis in nucleoli