Table 2.

Summary of the correlation of expression profiles between estrogen and chemicals revealed by DNA microarray assay

Chemical	Cell line	R value	p value	Reference
High correlation (R = 0.8–0.9)
Zearalanone	MCF-7	0.96	<0.01	Parveen et al. [56]
Zearalenone	MCF-7	0.95	<0.01	Parveen et al. [56]
α-Zearalanol	MCF-7	0.95	<0.01	Parveen et al. [56]
β-Zearalanol	MCF-7	0.94	<0.01	Parveen et al. [56]
α-zearalenol	MCF-7	0.93	<0.01	Parveen et al. [56]
Bisphenol B	MCF-7	0.93	<0.01	Terasaka et al. [53]
Estriol	MCF-7	0.93		Terasaka et al. [44]
Genistein	MCF-7	0.93		Ise et al. [52]
p-Hydroxybenzophenone	MCF-7	0.92	<0.01	Terasaka et al. [53]
Genistein	MCF-7	0.91		Terasaka et al. [44]
Nonylphenol	MCF-7	0.90	<0.01	Terasaka et al. [53]
Bisphenol A	MCF-7	0.89	<0.01	Terasaka et al. [53]
C-heavy oil (TK09 W, 73d)	MCF-7	0.88		Zhu et al. [55]
Estrone	T-47D	0.87	<0.01	Inoue et al. [57]
Diethylstilbestrol	T-47D	0.87	<0.01	Inoue et al. [57]
Nonylphenol	MCF-7	0.86		Terasaka et al. [44]
Butylbenzyl phthalate	MCF-7	0.85	<0.01	Parveen et al. [58]
Estrone	MCF-7	0.85		Terasaka et al. [44]
Agaricus blazei extract	MCF-7	0.84	<0.01	Dong et al. [45]
Estriol	T-47D	0.83	<0.01	Inoue et al. [57]
4n-Heptylphenol	MCF-7	0.82	<0.01	Terasaka et al. [53]
β-Zearalenol	MCF-7	0.82	<0.01	Parveen et al. [56]
C-heavy oil (TK09 W, 101d)	MCF-7	0.82		Zhu et al. [55]
Medium correlation (R = 0.4–0.8)
Biochanin A	MCF-7	0.79		Ise et al. [52]
Phloretin	MCF-7	0.78		Ise et al. [52]
4-t-octylphenol	MCF-7	0.75	<0.01	Terasaka et al. [53]
Daidzein	MCF-7	0.74		Ise et al. [52]
Coumestrol	MCF-7	0.74		Ise et al. [52]
Propylparaben	MCF-7	0.74	<0.01	Terasaka et al. [53]
Bisphenol A	T-47D	0.72	<0.01	Inoue et al. [57]
Naringenin	MCF-7	0.70		Ise et al., 2005 [52]
C-heavy oil (HP-7, 73d)	MCF-7	0.70		Zhu et al. [55]
Diethylstilbestrol	MCF-7	0.69		Terasaka et al. [44]
Kaempferol	MCF-7	0.68		Ise et al. [52]
Apigenin	MCF-7	0.67		Ise et al. [52]
Chrysin	MCF-7	0.66		Ise et al. [52]
Ginsenoside F1	MCF-7	0.66	<0.01	Dong and Kiyama, 2009 [60]
Bisphenol A	MCF-7	0.65		Terasaka et al. [44]
Luteolin	MCF-7	0.64		Ise et al. [52]
Brefeldin A	MCF-7	0.61		Dong et al. [54]
Butylparaben	MCF-7	0.60	<0.01	Terasaka et al. [53]
Glycitein	MCF-7	0.59		Ise et al. [52]
C-heavy oil (TK09 W, 28d)	MCF-7	0.57		Zhu et al. [55]
Methoxychlor	MCF-7	0.56		Terasaka et al. [44]
Quercetin	MCF-7	0.53		Ise et al. [52]
Diethyl phthalate	MCF-7	0.52	<0.01	Parveen et al. [58]
Genistein	T-47D	0.52	<0.01	Inoue et al. [57]
Diisopropyl phthalate	MCF-7	0.49	<0.01	Parveen et al. [58]
Nonylphenol	T-47D	0.49	<0.01	Inoue et al. [57]
G. glabra root extract	MCF-7	0.47	<0.01	Dong et al. [59]
Low or no correlation (R < 0.4)
4-n-ethylphenol	MCF-7	0.39	<0.01	Terasaka et al. [53]
Ginsenoside Rb1	MCF-7	0.38	<0.01	Dong and Kiyama [60]
Dibutyl phthalate	MCF-7	0.36	<0.01	Parveen et al. [58]
Pentachlorophenol	MCF-7	0.32	<0.01	Terasaka et al. [53]
4-chloro-3,5-dimetylphenol	MCF-7	0.26	<0.01	Terasaka et al. [53]
Ginsenoside Rh1	MCF-7	0.22	0.01–0.05	Dong and Kiyama [60]
Ginsenoside Rg1	MCF-7	0.21	0.01–0.05	Dong and Kiyama [60]
Dioxin (TCDD)	MCF-7	0.21		Terasaka et al. [44]
C-heavy oil (control, 73d)	MCF-7	0.21		Zhu et al. [55]
Ipriflavone	MCF-7	0.19		Ise et al. [52]
Ethylparaben	MCF-7	0.19	0.01–0.05	Terasaka et al. [53]
4-chlorophenol	MCF-7	0.15	>0.05	Terasaka et al. [53]
p-cresol	MCF-7	0.12	>0.05	Terasaka et al. [53]
2,4-dichlorophenol	MCF-7	0.03	>0.05	Terasaka et al. [53]
Methylparaben	MCF-7	−0.21	0.01–0.05	Terasaka et al. [53]
Glycyrrhizin	MCF-7	No correlation		Dong et al. [59]

Data were reproduced from the references shown on the right. The gene expression profile of each chemical was obtained after either MCF-7 or T-47D cells had been treated with the chemical and compared with that of 17β-estradiol (E₂) obtained from the same cell line. Coefficients of correlation (R values) between each chemical and E₂ on the basis of linear regression and p values for the statistical significance of the correlation were calculated