Fig. 6.

Ribbon representations of homophilic and heterophilic interfaces of nectins. a Homodimer interface of human nectin-2 (PDB ID: 3R0N) showing the close proximity of two negatively charged side chains; Glu-141 is contributed from the F strand of each monomer (yellow and gray). b Dimeric interface of nectin-1 (PDB ID: 3ALP) showing the similar unfavorable repulsive electrostatics as depicted in case of nectin-2. c Molecular model showing the heterodimer interface of nectin-2 (yellow) and nectin-3 (brown). The modeling suggests that E141 of nectin-2 contacts K149 of nectin-3, forming a putative polar interaction at the center of the dimer interface which favors a strong heterophilic interaction